ConSEPT: Convulsive Status Epilepticus Paediatric Trial

What is best practice for physician management of prolonged seizures in children?

Grant ID: EMPJ-105R21-2014

Lay Summary

Convulsive Status Epilepticus (CSE) is the most common childhood neurological emergency, sometimes resulting in death or serious disability. CSE is managed with anticonvulsant medications in a step-wise approach until seizures stop. While some management strategies for CSE are well supported by evidence (e.g. initial administration of benzodiazepines), subsequent strategies are based on expert consensus and not evidence.

Phenytoin, the traditional second line agent for CSE has a high failure rate, causes adverse events and must be administered slowly. Levetiracetam, a newer anticonvulsant, has a favourable adverse events profile, can be administered quickly and has good efficacy for various seizure types.

This research project proposes to undertake a randomised controlled trial of the second line anticonvulsants phenytoin and levetiracetam for CSE in children. This multi-centre study will be a world first and have a profound impact on the management of CSE in children in New Zealand, Australia and worldwide, in either confirming the current second line medication used or recommending a newer second line medication.

Leveraged Funds

- $77,523.16 Private Practice Trust Funding


- Dalziel S. R., Furyk J., Bonisch M., Oakley E., Borland M., Neutze J., Donath S., Sharpe C., Harvey S., Davidson A., Craig S., Phillips N., George S., Rao A., Cheng N., Zhang M., Sinn K., Kochar A., Brabyn C., Babl F.E., “A multicentre randomised controlled trial of levetiracetam versus phenytoin for convulsive status epilepticus in children (protocol): Convulsive Status Epilepticus Paediatric Trial (ConSEPT) - a PREDICT study”, 'BMC Pediatrics', 2017;17(1):152. doi:10.1186/s12887-017-0887-8



Amount Awarded


Grant Scheme


Principal Investigator:
Dr Jeremy Furyk

Co Investigators:
Dr Natalie Phillips
Dr Shane George

Associate Investigators:
Ms Jenine Lawlor
A/Prof Ed Oakley
A/Prof Franz Babl
Dr Stuart Dalziel


Collaborating Institutions

CONTACT US +61 7 3720 5700 Suite 1B, Terraces, 19 Lang Parade, Milton Qld 4064