Traumatic injuries in children are a leading cause of death and disability in Australia. In high income countries, 40% of child deaths are because of traumatic injuries. Fibrinogen is one of the key clotting factors that need to be replaced in severe traumatic bleeding.
Currently, fibrinogen is replaced using cryoprecipitate; a blood product obtained from healthy volunteer donors. This is a precious resource that is stored frozen in the blood bank; it can take a long time to administer and place significant strain on blood banks. Fibrinogen concentrate (FC) is an alternative product used to assist in blood clotting. It is a product that is derived from blood plasma but stored in powder form and can be reconstituted at the bedside and given quickly. The study will investigate whether it is quicker to administer FC than cryoprecipitate, which may reduce haemorrhage and improve outcomes.
This study will enrol 30 children from three major paediatric trauma centres in Queensland admitted with severe traumatic bleeding. Time to administration of fibrinogen replacement and the effect of fibrinogen levels will be measured.
- George, S., Wake, E., Sweeny, A., Campbell, D. and Winearls, J., 2022. Rotational thromboelastometry in children presenting to an Australian major trauma centre: A retrospective cohort study. Emergency Medicine Australasia, 34(4), pp.590-598. doi: 10.1111/1742-6723.13939
- Gold Coast University Hospital (GCUH) ED Emergency Research Forum 2022 - Oral Presentation
- ACEM ASM Perth 2018: George, S. Getting a Little FEISTY - Fibrinogen Replacement in Paediatric Trauma
- Gold Coast University Hospital (GCUH) Research Week Nov 2018: Dr Shane George presentation
Dr Christa Bell
Dr Shane George
Dr James Winearls
Dr Melanie Jansen
Dr John Roy
Dr Andrew Blanch
Dr Christian Stocker
Dr Emma Cottle
Ms Elizabeth Wake
Dr Glenn Ryan
Dr Catherine Hurn
Dr Greg Wiseman