Fibrinogen Early In Severe Trauma studY II (FEISTY II)

Grant ID: EMPJ-201R29-2018

Lay Summary

In a severe trauma, major bleeding or haemorrhaging is associated significant morbidity and mortality. Haemorrhage can be compounded by Trauma Induced Coagulopathy. It is postulated that early replacement of low fibrinogen levels may reduce haemorrhage and improve outcomes. Fibrinogen concentrate is an alternative way to replace fibrinogen.

In the FEISTY pilot trial, we demonstrated that a guided fibrinogen replacement strategy utilising either fibrinogen concentrate or cryoprecipitate is feasible. We found that fibrinogen concentrate was significantly faster to administer. The follow-on FEISTY II Trial will evaluate relevant patient-centred endpoints of a guided dose of FC Vs cryoprecipitate in traumatic haemorrhage. This larger study builds on the success of FEISTY to include multiple trauma centres in Australia and overseas.


Amount Awarded


Grant Scheme


Principal Investigator:
Dr Don Campbell

Co Investigators:
Dr James Winearls
Dr Glenn Ryan
Dr Jeff Presneill
Dr Michael Reade
Dr Wayne Dwyer
Prof Gerben Keijzers
Prof Dev Mitra
Prof John Fraser

Associate Investigators:
Prof Martin Wullschleger
Dr James Walsham
Dr Anthony Holley
Dr Melita Trout
Dr Jeremy Hsu
Dr David Roxby
Prof Bala Venkatesh
Dr Phillip Mondy


Collaborating Institutions


  • Linked EMF grant: FEISTY – Fibrinogen Early In Severe Trauma study
  • Linked EMF grant: Fibrinogen Early In Severe Trauma in children studY (FEISTY Junior)
  • FEISTY website

  • CONTACT US +61 7 3720 5700 Suite 1B, Terraces, 19 Lang Parade, Milton Qld 4064