Research Portfolio

Examining the effectiveness of Brown snake antivenom

The amount of Brown snake antivenom required to properly neutralise the venom delivered in a brown snake bite remains controversial. Using appropriate amounts reduces the risks and side effects of antivenom, while optimising its positive effects. One of the major clinical symptoms of Brown snake bite is massive bleeding. We aim to use a novel method for analysis of blood clotting (the ROTEM analyser) to study the effects of Brown snake venom on blood clotting and how different doses of antivenom affect this. This information may enable us to develop a simple point of care test to determine the optimal…

Principal Investigator: Dr Adam Holyoak
Amount Awarded: $46,000
Institution:

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Single centre validation of the Canadian Syncope Risk Score

Syncope is a transient loss of consciousness with full recovery, and is a common presenting problem to the emergency department (ED). Most patients presenting with syncope have a benign cause, but others may be at risk for serious adverse outcomes. The problem is that there is currently no validated tool for knowing which patients are at risk and which can be safely discharged. Several clinical prediction rules have been developed over the years, however the sensitivity and specificity of these rules vary. This has led to an over-admission of patients who could otherwise be safely discharged, based on clinician discretion.…

Principal Investigator: Dr Jason Chan
Amount Awarded: $59,804
Institution:

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Research capacity building: Redcliffe Hospital

Redcliffe Hospital Emergency Department (ED) has a growing research track record and an increasing number of clinical staff engaging in research-related activities. To capitalise on this burgeoning interest, we will funding a dedicated Clinical Research Coordinator to provide active support, coordination and promotion of both current and future research activities. The aim of our endeavour is to establish research as a core element of ED activity, together with education & training, provision of clinical care and maintenance of standards in healthcare. We intend to conduct our future research under the auspices of leaders and champions representing four thematic headings: 1.…

Principal Investigator: A/Prof Douglas Morel
Amount Awarded: $108,440
Institution:

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Assessing Children’s Head Injury: Variation in CT scan use (APHIRST-Gap)

This study will collect information from the records of 3000 children from 30 hospitals presenting after a head injury in 2016 and will interview staff to look at different factors influencing the care provided. APHIRST-Gap is expected to provided crucial information on scan rates and inform strategies, including national guideline development to standardise and improve the care of children with head injury across Australia and New Zealand. Head injury is a common reason children present to Emergency Departments in Australia and New Zealand. While most are minor the important issue for emergency clinicians is to determine whether a particular child…

Principal Investigator: Dr Natalie Phillips
Amount Awarded: $62,749
Institution:

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Preventing chronic pain after whiplash injury

After whiplash injury, half of patients never fully recover. The human and economic cost is enormous, and current mainstay treatments are ineffective. Most recovery, if it occurs, takes place in the first two to three months. This early time period offers a ‘window of opportunity’ to pro-actively intervene and prevent the chronic pain. The Emergency Department (ED) is ideally placed to provide very early intervention. We have shown that upregulation of pain in the central nervous system occurs soon after whiplash injury and predicts poor recovery. We aim to target these central nervous system processes with pregabalin in conjunction with…

Principal Investigator: Professor Gerben Keijzers
Amount Awarded: $83,639
Institution:

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