Sedation for Acute Agitation in Emergency Department Patients: Targeting Adverse Events (SIESTA)

The aim is to determine the nature and incidence of adverse events associated with parenteral sedation medication administered to acutely agitated patients in the ED, and to determine the risk factors for these adverse events.

Grant ID: EMTR-101R23-2015

Lay Summary

Acutely agitated patients are commonly seen in the emergency department (ED). As these patients may cause harm to themselves or others, a large proportion need to be managed with injectable sedative medications such as benzodiazepines (eg midazlolam) and/ or antipsychotics (e.g droperidol).
Unfortunately, these medications may precipitate life threatening events (e.g hypoventilation). Safety data related to the use of these medications for the management of acute agitation in the ED setting are scant. Acute agitation in the ED setting is usually caused by mental health issues or substance abuse, again little is known about which sedative medications are best suited for different groups of acutely agitated patients.

The aim of this study is to determine the nature and incidence of adverse events associated with parenteral sedation medication administered to acutely agitated patients in the ED and to determine the risk factors for these adverse events. It is a multicentre national observational study, aiming to recruit 2000 patients over the age of 18, over a 2 year period. It is hoped that the evidence this study generates will define the risk of AE in this population and may guide clinicians in future treatment choices in sedating this challenging group of patients, hopefully reducing future AE.


Video/Presentations

http://www.abc.net.au/news/2016-02-22/sedation-study-looks-into-violent-abusive-hospital-patients/7190070
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Amount Awarded
$17,639


Program


Grant Scheme


Status
Active


Principal Investigator:
Dr Barrie Field


Co Investigators:
Prof David Taylor


Supervisor:
Dr Ogilvie Thom


Institution


Collaborating Institutions


CONTACT US +61 7 3720 5700 info@emfoundation.org.au 2/15 Lang Parade Milton Qld 4064