Is prednisolone an effective treatment for Bell’s Palsy in children?

Grant ID: EMSS-312R26-2016

Lay Summary

Bell’s palsy or acute idiopathic lower motor neurone facial paralysis is characterised by sudden onset paralysis or weakness of the muscles to one side of the face controlled by the facial nerve. It is the third most common neurological reason for children to present acutely to hospital.

In adults, there is conclusive evidence from two major recent trials that a short course of prednisolone, a cheap, widely available and safe steroid, can significantly increase the number of Bell’s palsy patients who completely recover. While the medical problems associated with Bell’s palsy are similar, in children there is no good evidence that prednisolone is an effective treatment.

Many neurological conditions progress differently in children and treatment methods sometimes vary. Children may react differently to prednisolone and without paediatric evidence; treatment guidelines for children with Bell’s palsy remain absent or vague, with variable and overall low rates of steroid use in children by physicians.

The lack of evidence and clinical uncertainty in the treatment of Bell’s palsy in children warrants a definitive trial to determine the efficacy of prednisolone as a treatment for this condition in children. The aim of this study is to assess the utility of steroids in Bell’s palsy in children in a large multicentre randomised, placebo-controlled, trial. The trial will take place in at least 10 hospitals within Australia and New Zealand, involving more than 500 children.


Leveraged Funds

- $1,136,210.69 [NHMRC 2015-20 Project Grant – Managed by Murdoch Children’s Research Institute]


Dissemination

> Babl F. E. et al, "Bell’s Palsy in Children (BellPIC): protocol for a multicentre, placebo-controlled randomized trial", BMC Pediatr., 2017 Feb 13. doi: 10.1186/s12887-016-0702-y
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307816/]

> Babl F. E. et al, "Bell's Palsy in children: Current treatment patterns in Australia and New Zealand. A PREDICT study: Bell's palsy", J Paediatr Child Health, Epub 2017 Feb 8. doi: 10.1111/jpc.13463 [http://onlinelibrary.wiley.com/doi/10.1111/jpc.13463/abstract;jsessionid=874460EFA8B728D4F1684B19CBB1163E.f02t01]


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Amount Awarded
$68,179


Program


Grant Scheme


Status
Active


Principal Investigator:
Dr Shane George


Co Investigators:
A/Prof Franz Babl
Dr Mark Mackay
Dr Stuart Dalziel
A/Prof Ed Oakley
A/Prof Meredith Borland
Dr Karthik Velusamy
Dr David Herd
Dr Ben Lawton


Institution


Collaborating Institutions


Media

  • The Mercury, 12 April 2017
  • Gold Coast Bulletin, 12 April 2017
  • CONTACT US +61 7 3720 5700 info@emfoundation.org.au 2/15 Lang Parade Milton Qld 4064