C.R.A.S.H. study: A randomised study of tissue oxygenation in an ovine model of haemorrhagic shock comparing the effect of colloid, fresh red cells, aged red cells and saline.

We will assess the amount of oxygen getting to the key organs (heart, brain and kidney) and how well the different fluids achieve their aim – namely to improve organ function, using other tests to show how well these organs function after fluid administration.

Grant ID: PROJ-2009-015-STAIB-CRASH

Lay Summary

Blood loss is a major cause of early deaths after trauma, accounting for 51% of the deaths occurring during the initial 48 hours after hospital admission. Decisions made in the early treatment of severe blood loss have important consequences for patient survival and length of time in the Intensive Care Unit. Red blood cell (RBC) transfusion is a key component of the management in acute haemorrhagic shock, based on the assumption that transfused RBCs improve delivery of oxygen to the tissues. However existing evidence suggests this may not be the case. Recent studies suggest however that transfusion of older blood may worsen both morbidity and mortality in certain patient subgroups. The aetiology behind this association shown in this retrospective study is unclear, but seems related to an alteration in risk/benefit profile of old vs new blood. Hence, this project will investigate the ability of typical fluids used in haemorrhagic shock in ED departments to improve oxygen delivery to vital organs following severe haemorrhage.


Amount Awarded


Grant Scheme


Principal Investigator:
Dr Andrew Staib

Co Investigators:
Dr James Collier
Dr Lin Fung
Dr Paul McMurray
Dr Kathryn Colebourne
Dr Adrian Barnett
Mr Kimble Dunster
Mr John-Paul Tung
John Fraser


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