SARS-CoV2 infection and immunity in frontline hospital staff during the COVID-19 pandemic

Grant ID: EMSF-006COV-2020-KING

Project Summary

Health workers are at increased risk of exposure and infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). The implications of healthcare worker infection are wide-reaching and impact not only the worker, but also have implications for nosocomial spread in the pre-symptomatic phase and depletion of the skilled workforce required to manage an increased volume of presentations.

Front-line health care workers represent a unique cohort to follow for trends in SARS-CoV-2 infection, immune response and antibody production as well as monitoring for re-infection. Understanding the implications of staff infection on the potential for long-lasting immunity is of key significance to staff and leaders of EDs. Equally, understanding of asymptomatic staff infection can inform policy regarding routine screening of staff to minimise the risk of nosocomial spread to other staff and patients.

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Leveraged Funds

- Gold Coast Health - Study Education and Research Trust Fund, 2020, $10,000

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Dissemination

Publication:

- Khoo, W.H., Jackson, K., Phetsouphanh, C., Zaunders, J.J., Alquicira-Hernandez, J., Yazar, S., Ruiz-Diaz, S., Singh, M., Dhenni, R., Kyaw, W., Tea, F., Merheb, V., Lee, F.X.Z., Burrell, R., Howard-Jones, A., Koirala, A., Zhou, L., Yuksel, A., Catchpoole, D.R., Lai, C.L., Vitagliano, T.L., Rouet, R., Christ, D., Tang, B., West, N.P., George, S., Gerrard, J., Croucher, P.I., Kelleher, A.D., Goodnow, C.G., Sprent, J.D., Powell, J.E., Brilot, F., Nanan, R., Hsu, P.S., Deenick, E.K., Britton, P.N., Phan, T.G.., 2023. Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19. Clinical Immunolology, 246:109209. doi: 10.1016/j.clim.2022.109209. Epub 2022 Dec 17. PMID: 36539107; PMCID: PMC9758763.

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