D.dimer adjusted to low clinical probability in the diagnosis of suspected pulmonary embolism – is it safe in the urban emergency department?

Grant ID: EMJS-367R34-2020-FURLONG

Project Summary

Pulmonary embolism (PE) is the third most common presenting acute cardiovascular syndrome behind myocardial infarction and cerebral vascular event, resulting in significant harm and death. Different clinical decision-making rules exist to guide clinicians investigating PE, to risk stratify patients based on presenting signs and symptoms; into low, moderate or high-risk. This helps direct further investigations and imaging, such as blood tests (D.dimer), computed tomography pulmonary angiogram (CTPA), and ventilation/perfusion scan (V/Q).

Currently, a blood test is a first line test used to help identify which lower risk patients might require further investigation with medical imaging. Medical imaging adds cost, prolongs hospital stay and exposes the patient to radiation and IV contrast. This retrospective study will determine in the Australian context, whether applying a higher cut off D.dimer to low risk patients who present to an urban emergency department is a safe strategy in ruling out PEs. An Australian study is important due to significant contextual issues in the D.dimer testing across different countries despite decision rules currently available.


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Amount Awarded
$21,783


Program


Grant Scheme


Status
Active


Principal Investigator:
Dr Karen Furlong


Associate Investigators:
Dr Sean Clark
Dr Christopher Carty
Dr Zaheerodin Bhikoo
Stacey Watts


Institution



CONTACT US +61 7 3720 5700 info@emfoundation.org.au Suite 1B, Terraces, 19 Lang Parade, Milton Qld 4064