Vasopressor Infusion via Peripheral vs Central Access in emergency department patients with shock – The VIPCA RCT

Grant ID: EMJS-411R37-2022-HOLLAND

Project Summary

Shock is an umbrella description for poor blood supply to vital organs, and can lead to multi-organ failure and death. Emergency department (ED) patients with shock are amongst the sickest, with 1/3 being admitted to an intensive care unit (ICU). Low blood pressure, a key feature of shock which causes the poor blood supply to vital organs, can be treated with medications called vasopressors. Vasopressors traditionally have been given through a so-called 'central line'. Central lines are invasive to insert and require skill, and the actual insertion can lead to complications. More evidence has emerged that so-called peripheral lines (aka 'drip') are safe for vasopressor infusion. Randomised controlled trials (RCT) to compare the two strategies will provide high quality data to inform clinicians as to which approach is best for patients, staff and the healthcare budget. We propose a feasibility RCT to test processes and inform a large phase-III RCT to definitively answer this question.


Amount Awarded


Grant Scheme


Principal Investigator:
Dr Thomas Holland

Co Investigators:
Dr Mahesh Ramanan
Prof Gerben Keijzers
Dr Yogesh Apte
Ms Stacey Watts

Associate Investigators:
Prof Robert Ware
Prof Joshua Byrnes
Dr Alison Craswell
A/Prof Frances Lin
A/Prof Chris Anstey
Dr Alexis Tabah


Collaborating Institutions

CONTACT US +61 7 3720 5700 Suite 1B, Terraces, 19 Lang Parade, Milton Qld 4064