Vasopressor Infusion via Peripheral vs Central Access in emergency department patients with shock – The VIPCA RCT
Grant ID: EMJS-411R37-2022-HOLLAND
Project Summary
Shock is an umbrella description for poor blood supply to vital organs, and can lead to multi-organ failure and death. Emergency department (ED) patients with shock are amongst the sickest, with 1/3 being admitted to an intensive care unit (ICU). Low blood pressure, a key feature of shock which causes the poor blood supply to vital organs, can be treated with medications called vasopressors. Vasopressors traditionally have been given through a so-called 'central line'. Central lines are invasive to insert and require skill, and the actual insertion can lead to complications. More evidence has emerged that so-called peripheral lines (aka 'drip') are safe for vasopressor infusion. Randomised controlled trials (RCT) to compare the two strategies will provide high quality data to inform clinicians as to which approach is best for patients, staff and the healthcare budget. We propose a feasibility RCT to test processes and inform a large phase-III RCT to definitively answer this question.
Dissemination
Publication:
- Watts, S., Apte, Y., Holland, T., Hatt, A., Craswell, A., Lin, F., Tabah, A., Ware, R., Byrnes, J., Anstey, C. and Keijzers, G., 2024. Randomised, controlled, feasibility trial comparing vasopressor infusion administered via peripheral cannula versus central venous catheter for critically ill adults: A study protocol. Plos one, 19(5), p.e0295347.
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