Adding “insult to Injury” – The Effect of fresh and aged blood to oxygenation metabolisms and organ function in a clinically relevant trauma/sepsis model.

The World Health Organization reports that trauma will be the major contributor to the 49.7 million annual deaths globally from non–communicable disease in 2020. Trauma and sepsis are the two leading causes of death worldwide. This project aims to examine the effects of trauma and severe infection on oxygen supply to various tissues and organs.
We will study what infection does to metabolism and the degree of inflammation in these tissues. The effects of resuscitation on these tissue parameters while using stored and fresh blood will also be studied.