Fibrinogen Early In Severe Trauma in children studY (FEISTY Junior)

Grant ID: EMPJ-371R27-2017

Project Summary

Traumatic injuries in children are a leading cause of death and disability in Australia. In high income countries, 40% of child deaths are because of traumatic injuries. Fibrinogen is one of the key clotting factors that need to be replaced in severe traumatic bleeding.

Currently, fibrinogen is replaced using cryoprecipitate; a blood product obtained from healthy volunteer donors. This is a precious resource that is stored frozen in the blood bank; it can take a long time to administer and place significant strain on blood banks. Fibrinogen concentrate (FC) is an alternative product used to assist in blood clotting. It is a product that is derived from blood plasma but stored in powder form and can be reconstituted at the bedside and given quickly. The study will investigate whether it is quicker to administer FC than cryoprecipitate, which may reduce haemorrhage and improve outcomes.

This study will enrol 30 children from three major paediatric trauma centres in Queensland admitted with severe traumatic bleeding. Time to administration of fibrinogen replacement and the effect of fibrinogen levels will be measured.

Dissemination

Publication:

- George, S., Wake, E., Sweeny, A., Campbell, D. and Winearls, J., 2022. Rotational thromboelastometry in children presenting to an Australian major trauma centre: A retrospective cohort study. Emergency Medicine Australasia, 34(4), pp.590-598. doi: 10.1111/1742-6723.13939

Presentations:

- Gold Coast University Hospital (GCUH) ED Emergency Research Forum 2022 - Oral Presentation

- ACEM ASM Perth 2018: George, S. Getting a Little FEISTY - Fibrinogen Replacement in Paediatric Trauma

- Gold Coast University Hospital (GCUH) Research Week Nov 2018: Dr Shane George presentation

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