Fibrinogen Early In Severe Trauma in children studY (FEISTY Junior)

Grant ID: EMPJ-371R27-2017

Lay Summary

Traumatic injuries in children are a leading cause of death and disability in Australia. In high income countries, 40% of child deaths are because of traumatic injuries. Fibrinogen is one of the key clotting factors that need to be replaced in severe traumatic bleeding.

Currently, fibrinogen is replaced using cryoprecipitate; a blood product obtained from healthy volunteer donors. This is a precious resource that is stored frozen in the blood bank; it can take a long time to administer and place significant strain on blood banks. Fibrinogen concentrate (FC) is an alternative product used to assist in blood clotting. It is a product that is derived from blood plasma but stored in powder form and can be reconstituted at the bedside and given quickly. The study will investigate whether it is quicker to administer FC than cryoprecipitate, which may reduce haemorrhage and improve outcomes.

This study will enrol 30 children from three major paediatric trauma centres in Queensland admitted with severe traumatic bleeding. Time to administration of fibrinogen replacement and the effect of fibrinogen levels will be measured.


SHARE

Amount Awarded
$100,000


Program


Grant Scheme


Status
Active


Principal Investigator:
Dr Christa Bell


Co Investigators:
Dr Shane George
Dr James Winearls
Dr Melanie Jansen
Dr John Roy
Dr Andrew Blanch
Dr Christian Stocker


Associate Investigators:
Dr Emma Cottle
Ms Elizabeth Wake
Dr Glenn Ryan
Dr Catherine Hurn
Dr Greg Wiseman


Institution


Collaborating Institutions


Links

  • FEISTY trial in adults

  • CONTACT US +61 7 3720 5700 info@emfoundation.org.au 2/15 Lang Parade Milton Qld 4064