Early resuscitation in paediatric sepsis

A randomised controlled pilot study

Grant ID: EMPJ-207R29-2018

Lay Summary

Sepsis is a leading cause of death and disability in children, globally accounting for more than one million childhood deaths per year. Recommended sepsis treatment currently consists of intravenous antibiotics and aggressive fluid boluses followed by inotropes and consideration for intravenous steroids. However, the evidence for interventions other than antibiotics is limited and aggressive fluid administration may be associated with harm. Therefore, fluid-sparing algorithms using early inotropes to treat shock have been proposed. Another strategy to hasten shock resolution consists in intravenous steroids, alone or in combination with thiamine and vitamin C, postulated to support metabolic dysfunction in recent studies.

In this project, the research team is conducting a randomised controlled pilot trial in children presenting with septic shock. They are assessing the feasibility of a fluid-sparing algorithm using early inotropes and early intravenous administration of Vitamin C, Thiamine and Hydrocortisone and the impact on survival free of organ dysfunction.


SHARE

Amount Awarded
$99,975


Program


Grant Scheme


Status
Active


Principal Investigator:
Dr Megan King


Co Investigators:
A/Prof Luregn Schlapbach
Dr Shane George
A/Prof Andreas Schibler
Dr Elliot Long
Ms Amanda Harley
Prof Brenda Gannon
Prof Rinaldo Bellomo


Associate Investigators:
Dr Paula Lister
Dr Arjun Chavan
Dr Sandi Dawson
A/Prof Kirsten Gibbons
Dr Vinay Gangathimn
A/Prof Franz Babl


Institution


Collaborating Institutions


CONTACT US +61 7 3720 5700 info@emfoundation.org.au 2/15 Lang Parade Milton Qld 4064